The interplay of restriction-modification systems with mobile genetic elements and their prokaryotic hosts

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The interplay of restriction-modification systems with mobile genetic elements and their prokaryotic hosts

The roles of restriction-modification (R-M) systems in providing immunity against horizontal gene transfer (HGT) and in stabilizing mobile genetic elements (MGEs) have been much debated. However, few studies have precisely addressed the distribution of these systems in light of HGT, its mechanisms and its vectors. We analyzed the distribution of R-M systems in 2261 prokaryote genomes and found ...

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ژورنال

عنوان ژورنال: Nucleic Acids Research

سال: 2014

ISSN: 1362-4962,0305-1048

DOI: 10.1093/nar/gku734